Course Title: Reactive Intermediates
Course Code: CHEM-603
Credit Hours: 3(3-0)
Course Objectives:
Students will acquire knowledge regarding the rearrangement reactions and their types including some name reactions, and different intermediates involved in organic reactions. Students are expected to learn the underlying concepts and synthetic applications.

COURSE OUTLINE
Theory:
Reactive Intermediates: Carbocations, carbanions, free radicals, carbenes, nitrenes, and arynes; their generation, stability, reactions and synthetic applications. Chemistry of Enolates and Enols: Acidity of carbonyl compounds, enolization of carbonyl compounds, α-halogenation of carbonyl compounds; aldol-addition and aldol-condensation, condensation reactions involving ester enolate ions, alkylation of ester enolates.

Rearrangement Reactions: Types of rearrangements, general mechanisms of nucleophilic, free radical and electrophilic rearrangements, hydrogen and/or carbon migration to electron-deficient carbon, nitrogen and oxygen, carbon migration to electron-rich carbon, aromatic rearrangements, inter- and intra-molecular carbon migration from oxygen to carbon.

Recommended Books:

1. Clayden, J., Greeves, N. and Warren, S., Organic Chemistry, 2nd ed., Oxford University Press (2012).

2. Coxon, J. M. and Norman, R.O.C., Principles of Organic Synthesis, 3rd ed., Chapman and Hall, UK, (1993).

3. Brown, W. H., Foote, C. S., Iverson, B. L. and Anslyn, E. V., Organic Chemistry, 6th ed., Brooks/Cole Learning (2012).

4. John, E. M., Organic Chemistry, 8th ed., Brooks/Cole Publishing Co. USA, (2012).

5. Robert, T. M. and Robert, N., Organic Chemistry, 6th ed., Prentice Hall, New Jersey (1992).